Variability (polymorphism) in the genes encoding the cytochrome P450 (CYP) family of enzymes affect the metabolism of drugs relevant to mental health. “This can help guide prescribing.” Is your patient a poor, normal, or ultrarapid metabolizer? ![]() By looking at genetics, you can predict which medications are more likely to work or not work for the individual patient,” and help determine the appropriate dose. “Pharmacogenomic testing identifies genetic variations that impact pharmacodynamics and pharmacokinetics. “Pharmacogenomics is what we talk about when we talk about how a person’s genes interact with their medication,” he said. Dr Lorenz spoke about the promise of pharmacogenomics in mental health disorders-and some early successes-in a webinar as part of the Quest Diagnostics Drug Monitoring podcast series. “Pharmacogenomics can take away much of the guesswork,” removing much of the hay, as it were, making the search faster and increasing the odds of success in choosing the right drug. Pharmacogenomics is beginning to change that, according to Raymond Lorenz, PharmD, Director and Medical Science Liaison for Neurology and Pharmacogenomics at Quest Diagnostics. Identifying the best treatment regimen for pain, depression, anxiety, or other disorders can be like finding a needle in a haystack. Titrating the right dose poses its own challenges, balancing the need to control symptoms with the risk of side effects. It may take several months to know whether the drug you prescribe is working, and if it’s not, it may take several more months to know if the next one is any better. If you have any questions about your drug test, contact your employer.Finding the right treatment, and the right dose, for your patient with chronic pain or a mental health disorder can be challenging. The final drug test result is directly reported to the employer ordering the test.
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